Impact of heat on biological concentrations of toluene and acetone resulting from exposure by inhalation: A pilot study
Type de document
Études primaires
Année de publication
2021
Langue
Anglais
Titre de la revue
Environmental Toxicology and Pharmacology
Résumé
Climatic conditions raise new concerns about the potential impact of heat on the absorption and kinetics of certain chemicals. The impact of 3 temperatures (21, 25 and 30 °C WBGT) on the toxicokinetics of toluene and acetone was therefore evaluated in five human subjects during controlled exposures in an inhalation chamber. Biological samples were collected and analyzed by GC–MS/MS. Increases between 4 and 85 % were observed for solvents concentrations in blood (30 vs 21 °C) while decreases in urine samples for acetone and o-cresol were measured at the end of the exposure period (4 h). Mean blood concentrations at 4 h are well correlated with temperature. Results suggest an increased absorption and/or a decreased elimination of volatile chemicals in the presence of heat. Higher increases of blood chemical concentrations were observed in heavier individuals. Further studies should include physiologically based toxicokinetic models to help in better understanding the mechanisms involved and their respective contribution.
Mots-clés
Toxicocinétique, Toxicokinetics, Lieu de travail chaud, Hot workplace, Thermorégulation, Regulation of body temperature, Solvant, Sovent, Toluène, Toluene, CAS 108883, Acétone, Acetone, CAS 67641, Évaluation de l'exposition, Exposure evaluation, Détermination expérimentale, Experimental determination, Test d'exposition, Exposure test
Numéro de projet IRSST
2013-0012
Citation recommandée
Marchand, A., Ménard, J., Brochu, P. et Haddad, S. (2021). Impact of heat on biological concentrations of toluene and acetone resulting from exposure by inhalation: A pilot study. Environmental Toxicology and Pharmacology, 88, article 103737. https://doi.org/10.1016/j.etap.2021.103737