Prevalent occupational exposures and risk of lung cancer among women: Results from the application of the Canadian Job-Exposure Matrix (CANJEM) to a combined set of ten case–control studies

Mengting Xu, University of Montreal Hospital Research Center (CRCHUM), Montreal, Canada
Vikki Ho, University of Montreal Hospital Research Center (CRCHUM), Montreal, Canada
Jérôme Lavoué, University of Montreal Hospital Research Center (CRCHUM), Montreal, Canada
Ann Olsson, International Agency for Research on Cancer (IARC/WHO), Lyon, France
Joachim Schüz, International Agency for Research on Cancer (IARC/WHO), Lyon, France
Lesley Richardson, University of Montreal Hospital Research Center (CRCHUM), Montreal, Canada
Marie-Elise Parent, Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, QC, Canada
John R. McLaughlin, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
Paul A. Demers, Occupational Cancer Research Centre, Ontario Health, Toronto, Canada
Pascal Guénel, Center for Research in Epidemiology and Population Health (CESP), Team Exposome and Heredity, U1018 Inserm, Institut Gustave Roussy, University Paris-Saclay, Villejuif, France
Loredana Radoi, Center for Research in Epidemiology and Population Health (CESP), Team Exposome and Heredity, U1018 Inserm, Institut Gustave Roussy, University Paris-Saclay, Villejuif, France
Heinz-Erich Wichmann, Institute of Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany
Wolfgang Ahrens, Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany
Karl-Heinz Jöckel, Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany
Dario Consonni, Epidemiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
Maria T. Landi, National Cancer Institute, Bethesda, MD, United States
Lorenzo Richiardi, Department of Medical Sciences, Cancer Epidemiology Unit, University of Turin, Turin, Italy
Lorenzo Simonato, Department of Cardiovascular Sciences and Public Health, University of Padova, Padova, Italy
Andrea 't' Mannetje, Research Centre for Hauora and Health, Massey University, Wellington, New Zealand
Beata Świątkowska, The Nofer Institute of Occupational Medicine, Lodz, Poland
John K. Field, Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, The University of Liverpool, Liverpool, United Kingdom
Neil Pearce, Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom
Jack Siemiatycki, University of Montreal Hospital Research Center (CRCHUM), Montreal, Canada

Type de document

Études primaires

Année de publication

2024

Langue

Anglais

Titre de la revue

American Journal of Industrial Medicine

Première page

200

Dernière page

213

Résumé

Background: Worldwide, lung cancer is the second leading cause of cancer death in women. The present study explored associations between occupational exposures that are prevalent among women, and lung cancer. Methods: Data from 10 case–control studies of lung cancer from Europe, Canada, and New Zealand conducted between 1988 and 2008 were combined. Lifetime occupational history and information on nonoccupational factors including smoking were available for 3040 incident lung cancer cases and 4187 controls. We linked each reported job to the Canadian Job-Exposure Matrix (CANJEM), which provided estimates of probability, intensity, and frequency of exposure to each selected agent in each job. For this analysis, we selected 15 agents (cleaning agents, biocides, cotton dust, synthetic fibers, formaldehyde, cooking fumes, organic solvents, cellulose, polycyclic aromatic hydrocarbons from petroleum, ammonia, metallic dust, alkanes C18+, iron compounds, isopropanol, and calcium carbonate) that had lifetime exposure prevalence of at least 5% in the combined study population. For each agent, we estimated lung cancer risk in each study center for ever-exposure, by duration of exposure, and by cumulative exposure, using separate logistic regression models adjusted for smoking and other covariates. We then estimated the meta-odds ratios using random-effects meta-analysis. Results and Conclusions: None of the agents assessed showed consistent and compelling associations with lung cancer among women. The following agents showed elevated odds ratio in some analyses: metallic dust, iron compounds, isopropanol, and organic solvents. Future research into occupational lung cancer risk factors among women should prioritize these agents. © 2024 The Authors. American Journal of Industrial Medicine published by Wiley Periodicals LLC.

Mots-clés

Cancer du poumon, Lung cancer, Femme, Woman, Évaluation de l'exposition, Exposure evaluation, Différence liée au sexe, Sex difference, Matrice emploi exposition, Employment exposure matrix, JEM, CANJEM, Analyse des données, Data analysis

Numéro de projet IRSST

n/a

Ce document n'est pas disponible pour le moment.

Partager

COinS