Impact of gold nanoparticles (AuNPs) in human neutrophils in vitro and in leukocytes attraction in vivo: A sex-based analysis

Type de document

Études primaires

Année de publication

2023

Langue

Anglais

Titre de la revue

Environmental Toxicology and Pharmacology

Résumé

Some differences exist between the male and female immune systems. Despite this, a sex-based analysis is not frequently performed in most studies. Knowing that inflammation is a common undesired effect observed resulting from nanoparticle (NP) exposure, we investigate here how gold NPs with a primary size of 20 (AuNP20) and 70 nm (AuNP70) will alter the biology of polymorphonuclear neutrophil cells (PMNs) isolated from men and women as well as their potential pro-inflammatory effect in vivo in male and female mice. We found that AuNP20 significantly delay apoptosis only in PMN isolated from men. The production of interleukin (IL)− 8 by PMNs was increased by both AuNPs regardless of sex although significance was only observed in AuNP20-induced PMNs. Using the murine air pouch model of inflammation, AuNPs did not induce a neutrophilic infiltration regardless of sex. In conclusion, AuNPs could differently alter the biology of PMNs according to sex. © 2023 Elsevier B.V.

Mots-clés

Nanoparticule, Nanoparticle, Or, CAS 7440575, Recherche in vitro, In vitro experiment, Leucocyte, Leukocyte, Différence liée au sexe, Sex difference

Numéro de projet IRSST

2017-0044

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