Excretion time courses of lambda-cyhalothrin metabolites in the urine of strawberry farmworkers and effect of coexposure with captan

Yélian Marc Bossou, Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, and Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, Main Station, P.O. Box 6128, Montreal, U436H3C 3J7, QC, Canada
Jonathan Côté, Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, and Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, Main Station, P.O. Box 6128, Montreal, U436H3C 3J7, QC, Canada
Louiza Mahrouche, Department of Chemistry, University of Montreal, MIL Building, Main Station, P.O. Box 6128, Montreal, H3C 3J7, QC, Canada
Marc Mantha, Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, and Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, Main Station, P.O. Box 6128, Montreal, U436H3C 3J7, QC, Canada
Naïma El Majidi, Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, and Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, Main Station, P.O. Box 6128, Montreal, U436H3C 3J7, QC, Canada
Alexandra Furtos, Department of Chemistry, University of Montreal, MIL Building, Main Station, P.O. Box 6128, Montreal, H3C 3J7, QC, Canada
Michèle Bouchard, Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, and Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, Main Station, P.O. Box 6128, Montreal, U436H3C 3J7, QC, Canada

Type de document

Études primaires

Année de publication

2022

Langue

Anglais

Titre de la revue

Archives of Toxicology

Première page

2465

Dernière page

2486

Résumé

There are limited literature data on the impact of coexposure on the toxicokinetics of pesticides in agricultural workers. Using the largely employed pyrethroid lambda-cyhalothrin (LCT) and fungicide captan as sentinel pesticides, we compared individual temporal profiles of biomarkers of exposure to LCT in strawberry field workers following an application episode of LCT alone or in coexposure with captan. Participants provided all urine voided over a 3-day period after an application of a pesticide formulation containing LCT alone (E1) or LCT mixed with captan (E2), and in some cases following re-entry in treated field (E3). Pyrethroid metabolites were measured in all urine samples, in particular 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethyl-cyclopropanecarboxylic acid (CFMP), 3-phenoxybenzoic acid (3-PBA), and 4-hydroxy-3-phenoxybenzoic acid (4-OH3PBA). There were no obvious differences in individual concentration–time profiles and cumulative excretion of metabolites (CFMP, 3-PBA, 4-OH3BPA) after exposure to LCT alone or in combination with captan. For most workers and exposure scenarios, CFMP was the main metabolite excreted, but time courses of CFMP in urine did not always follow that of 3-PBA and 4-OH3BPA. Given that the latter metabolites are common to other pyrethroids, this suggests that some workers were coexposed to pyrethroids other than LCT. For several workers and exposure scenarios E1 and E2, values of CFMP increased in the hours following spraying. However, for many pesticide operators, other peaks of CFMP were observed at later times, indicating that tasks other than spraying of LCT-containing formulations contributed to this increased exposure. These tasks were mainly handling/cleaning of equipment used for spraying (tractor or sprayer) or work/inspection in LCT-treated field according to questionnaire responses. Overall, this study provided novel excretion time course data for LCT metabolites valuable for interpretation of biomonitoring data in workers, but also showed that coexposure was not a major determinant of variability in exposure biomarker levels. Our analysis also pointed out the importance of measuring specific metabolites. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Mots-clés

Métabolite urinaire, Urinary metabolite, Cyhalothrine, Cyhalothrin, CAS 68085858, Captane, Captan, CAS 133062, Produit chimique agricole, Agricultural chemical, Travaux agricoles, Agriculture operation, Pesticide

Numéro de projet IRSST

2016-0003

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