Ambient exposures to selected volatile organic compounds and the risk of prostate cancer in Montreal

Auteurs

Mark S. Goldberg, Department of Medicine, McGill University, Montréal, QC, Canada, Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Hospital Centre, Montréal, QC, Canada
Sara Zapata-Marin, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, QC, Canada
France Labrèche, Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail, Montréal, QC, Canada, Department of Environmental and Occupational Health, School of Public Health, Université de Montréal, Montréal, QC, Canada, Centre de recherche en santé publique (CReSP), University of Montréal, CIUSSS Centre-Sud, Montréal, QC, Canada
Vikki Ho, Department of Social and Preventive Medicine, School of Public Health, Université de Montréal, Montréal, QC, Canada, Health Innovation and Evaluation Hub, Université de Montréal Hospital Research Centre (CRCHUM), Montréal, Canada
Eric Lavigne, Health Canada, Air Health Science Division, Ottawa, ON, Canada, United States, Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Université du Québec, Laval, QC, Canada
Marie-France Valois, Department of Medicine, McGill University, Montréal, QC, Canada
Marie-Elise Parent, Department of Social and Preventive Medicine, School of Public Health, Université de Montréal, Montréal, QC, Canada

Type de document

Études primaires

Année de publication

2022

Langue

Anglais

Titre de la revue

Environmental Epidemiology

Première page

E231

Résumé

Background: Little is known about environmental factors that may increase the risk of prostate cancer. We estimated associations between incident prostate cancer and environmental concentrations of five ambient volatile organic compounds (VOCs): benzene; n-decane; ethylbenzene; hexane; and 1,2,4-trimethylbenzene.

Methods: This study is based on a population-based case-control study of incident prostate cancer (PROtEuS) in men ≤ 75 years of age living in Montreal, Canada, in 2005 to 2012. We included 1172 cases and 1177 population controls. We had personal information, lifetime residential addresses, occupational exposures, and a variety of area-wide covariables. We inferred concentrations of the five VOCs using Bayesian geostatistical models using data from a dense environmental survey conducted in Montreal in 2005 to 2006. We used different sets of adjustments to estimate odds ratios (OR) and confidence intervals.

Results: We found nonlinear associations such that the ORs increased monotonically and then either flattened or fell off with increased exposures. The model that contained other environmental variables and contextual variables led to lower ORs and results were similar when we restricted analyses to controls recently screened or tested for prostate cancer or cases with low- or high-grade tumors. A change from the 5th to 25th percentile in mean environmental benzene levels led to an adjusted OR of 2.00 (95% confidence interval = 1.47, 2.71).

Conclusion: We found positive associations between prostate cancer and concentrations of benzene and ethylbenzene, independently of previous testing for prostate cancer or tumor grade, suggesting that exposure to certain ambient VOCs may increase incidence. © 2022 Wolters Kluwer Health. All rights reserved.

Mots-clés

Évaluation de l'exposition, Exposure evaluation, Composés organiques volatils, Volatile organic compounds, Cancer de la prostate, Prostatic cancer, Benzène, Benzene, CAS 71432, Decane, CAS 124185, Éthylbenzène, Ethylbenzene, CAS 100414, Hexane normal, Hexane, CAS 110543, Trimethyl-1, 2, 4 benzene, 1, 2, 4-trimethylbenzene, CAS 95636

Numéro de projet IRSST

n/a

Citation recommandée

Goldberg, M. S., Zapata-Marin, S., Labrèche, F., Ho, V., Lavigne, E., Valois, M. F. et Parent, M. E. (2022). Ambient exposures to selected volatile organic compounds and the risk of prostate cancer in Montreal. Environmental Epidemiology, 6(6), article e231. https://doi.org/10.1097/EE9.0000000000000231