Association between depression, lung function, and inflammatory markers in patients with asthma and occupational asthma

Auteurs

• Nicola J. Paine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom, Montreal Behavioural Medicine Centre, Research Centre, Centre Integree Universitaire de Services de Sante et de Services Sociaux, Hôpital du Sacré-Cœur de Montréal, J-3190, 5400 Gouin West, Montreal, H4J 1C5, QC, Canada
• Maryann F. Joseph, Montreal Behavioural Medicine Centre, Research Centre, Centre Integree Universitaire de Services de Sante et de Services Sociaux, Hôpital du Sacré-Cœur de Montréal, J-3190, 5400 Gouin West, Montreal, H4J 1C5, QC, Canada
• Simon L. Bacon, Montreal Behavioural Medicine Centre, Research Centre, Centre Integree Universitaire de Services de Sante et de Services Sociaux, Hôpital du Sacré-Cœur de Montréal, J-3190, 5400 Gouin West, Montreal, H4J 1C5, QC, Canada, Department of Exercise Science, Concordia University, Montreal, QC, CanadaFollow
• Cassandre A. Julien, Montreal Behavioural Medicine Centre, Research Centre, Centre Integree Universitaire de Services de Sante et de Services Sociaux, Hôpital du Sacré-Cœur de Montréal, J-3190, 5400 Gouin West, Montreal, H4J 1C5, QC, Canada, Department of Psychology, University of Québec at Montréal (UQAM), Montréal, QC, Canada
• André Cartier, Montreal Behavioural Medicine Centre, Research Centre, Centre Integree Universitaire de Services de Sante et de Services Sociaux, Hôpital du Sacré-Cœur de Montréal, J-3190, 5400 Gouin West, Montreal, H4J 1C5, QC, Canada, Department of Medicine, Université de Montréal, Montréal, QC, CanadaFollow
• Blaine Ditto, Department of Psychology, McGill University, Montréal, QC, CanadaFollow
• Hélène Favreau, Montreal Behavioural Medicine Centre, Research Centre, Centre Integree Universitaire de Services de Sante et de Services Sociaux, Hôpital du Sacré-Cœur de Montréal, J-3190, 5400 Gouin West, Montreal, H4J 1C5, QC, Canada
• Kim L. Lavoie, Montreal Behavioural Medicine Centre, Research Centre, Centre Integree Universitaire de Services de Sante et de Services Sociaux, Hôpital du Sacré-Cœur de Montréal, J-3190, 5400 Gouin West, Montreal, H4J 1C5, QC, Canada, Department of Psychology, University of Québec at Montréal (UQAM), Montréal, QC, Canada

Type de document

Études primaires

Année de publication

2019

Langue

Anglais

Titre de la revue

Journal of Occupational and Environmental Medicine

Première page

453

Dernière page

460

Résumé

Objective: Depression is associated with autonomic and immune dysregulation, yet this remains poorly explored in asthma. We assessed associations between depressive disorder, lung function, and inflammatory markers in patients under investigation for occupational asthma (OA).

Methods: One hundred twelve patients under investigation for OA (60% men) underwent a psychiatric interview to assess depressive disorder, and spirometry, a methacholine test, sputum induction, and specific inhalation challenge (SIC) to assess OA. Blood and sputum inflammatory markers were assessed.

Results: There was a statistically significant association between depressive disorder (P = 0.0195) and forced expiratory volume in 1 second (FEV1) responses, with the drop in FEV1 post-SIC smaller in patients with OA and depression, versus OA with no depression (P < 0.001).

Conclusion: The presence of depressive disorder may influence FEV1 in patients with OA, which may be via autonomic pathways. However, further studies are warranted in order to determine the mechanisms that underlie these effects. Copyright © 2019 The Author(s).

Mots-clés

Dépression, Depressive disorder, Poumon, Lung, Inflammation, Asthme, Asthma, Maladie professionnelle, Occupational disease

Numéro de projet IRSST

n/a

Citation recommandée

Paine, N. J., Joseph, M. F., Bacon, S. L., Julien, C. A., Cartier, A., Ditto, B., . . . Lavoie, K. L. (2019). Association between depression, lung function, and inflammatory markers in patients with asthma and occupational asthma. Journal of Occupational and Environmental Medicine, 61(6). https://doi.org/10.1097/JOM.0000000000001562