Disruption of central and peripheral circadian clocks in police officers working at night

Auteurs

Anna Koshy, Department of Psychiatry, Centre for Study and Treatment of Circadian Rhythms, McGill University, Montréal, QC, Canada, Department of Psychiatry, Laboratory of Molecular Chronobiology, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada
Marc Cuesta, Department of Psychiatry, Centre for Study and Treatment of Circadian Rhythms, McGill University, Montréal, QC, Canada, Department of Psychiatry, Laboratory of Molecular Chronobiology, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada
Philippe Boudreau, Department of Psychiatry, Centre for Study and Treatment of Circadian Rhythms, McGill University, Montréal, QC, Canada
Nicolas Cermakian, Department of Psychiatry, Laboratory of Molecular Chronobiology, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada
Diane B. Boivin, Department of Psychiatry, Centre for Study and Treatment of Circadian Rhythms, McGill University, Montréal, QC, Canada

Type de document

Études primaires

Année de publication

2019

Langue

Anglais

Titre de la revue

FASEB Journal

Première page

6789

Dernière page

6800

Résumé

Working atypical schedules leads to temporal misalignments between a worker's rest-activity cycle and their endogenous circadian system. Several studies have reported disturbed centrally controlled rhythms, but little is known on shift workers' peripheral clocks. Here, we assessed central clock markers, urinary 6-sulfatoxymelatonin and salivary cortisol, and clock gene expression in 2 peripheral clocks, oral mucosa cells and peripheral blood mononuclear cells (PBMCs), in 11 police officers. Before working 7 consecutive nights, officers' centrally controlled rhythms were aligned to a day-oriented schedule. These rhythms were partially realigned to the shifted schedule and dampened after a week working nights. For peripheral clocks at baseline, Period (PER)1–3 and nuclear receptor subfamily 1, group D, member 1 (REV-ERBα) in oral mucosa cells had a significant mRNA peak in the afternoon, whereas in PBMCs, higher PER1–3 expression was observed at 10:00 compared with 19:30. After a week working nights, PER1–3 and REV-ERBα expression in oral mucosa cells lost rhythmicity, and in PBMCs, the morning/evening difference observed at baseline was lost. To our knowledge, this is the first study to demonstrate the disruption of several peripheral clocks in real shift workers. Molecular circadian disturbances are believed to have important clinical implications for the occurrence of shift work–associated medical disorders.—Koshy, A., Cuesta, M., Boudreau, P., Cermakian, N., Boivin, D. B. Disruption of central and peripheral circadian clocks in police officers working at night. FASEB J. 33, 6789–6800 (2019). © FASEB

Mots-clés

Rythme circadien, Circadian rhythm, Travail de nuit, Night work, Police, Police force

Numéro de projet IRSST

2013-0046

Citation recommandée

Koshy, A., Cuesta, M., Boudreau, P., Cermakian, N. et Boivin, D. B. (2019). Disruption of central and peripheral circadian clocks in police officers working at night. FASEB Journal, 33(6), 6789-6800. https://doi.org/10.1096/fj.201801889R