Kinetic time courses of lambda-cyhalothrin metabolites after dermal application of Matador EC 120 in volunteers

Auteurs

Rania Khemiri, Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, Institute of Research in Public Health of the University of Montreal (IRSPUM), University of Montreal, Roger-Gaudry Building, U424, P.O. Box 6128, Main Station, Montreal, H3C 3J7, Quebec, Canada
Jonathan Côté, Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, Institute of Research in Public Health of the University of Montreal (IRSPUM), University of Montreal, Roger-Gaudry Building, U424, P.O. Box 6128, Main Station, Montreal, H3C 3J7, Quebec, Canada
Hamadi Fetoui, Laboratory of Toxicology-Microbiology and Environmental Health (LR17ES70), Faculty of Sciences, University of Sfax, BP 1171, Sfax, 3000, Tunisia
Michèle Bouchard, Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, Institute of Research in Public Health of the University of Montreal (IRSPUM), University of Montreal, Roger-Gaudry Building, U424, P.O. Box 6128, Main Station, Montreal, H3C 3J7, Quebec, Canada

Type de document

Études primaires

Année de publication

2018

Langue

Anglais

Titre de la revue

Toxicology Letters

Première page

132

Dernière page

138

Résumé

A controlled kinetic study was conducted in volunteers dermally exposed to the widely used lambda-cyhalothrin pyrethroid pesticide to document the time courses of relevant biomarkers of exposure, in order to better assess biomonitoring data in workers. Matador^® EC120 formulation (120 g/l) was applied on 40 cm² of the forearm at a 0.25 mg/kg dose of lambda-cyhalothrin and left without occlusion or washing for 6 h. The application site was then washed thoroughly with soap and water. The kinetic time courses of cis-3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane carboxylic acid (CFMP) and 3-phenoxybenzoic acid (3-PBA) metabolites were determined in plasma and urine up to 84 h post-application. Results show that the fraction of lambda-cyhalothrin absorbed in the body was rapidly cleared following dermal contact. According to CFMP and 3-PBA plasma profiles, calculated mean apparent absorption half-lives (t1/2) were 3 and 7.3 h, respectively, and corresponding mean apparent elimination t_1/2 were 11.2 and 7.6 h. These differences suggest some metabolism at the site-of-entry and storage of metabolites by the dermal route. Toxicokinetic parameters calculated from urinary profiles confirm the values of absorption and elimination rates. Metabolites were almost completely excreted over the 84-h period post-application and, on average, 0.12 and 0.08% of the applied lambda-cyhalothrin dose was recovered in the urine as CFMP and 3-PBA, respectively, indicating a low dermal absorption fraction of this pyrethroid. This study showed the potential use of CFMP and 3-PBA biomarkers for the assessment of dermal exposure to lambda-cyhalothrin pyrethroid. © 2018 Elsevier B.V.

Mots-clés

Métabolite urinaire, Urinary metabolite, Cyhalothrine, Cyhalothrin, CAS 68085858, Produit chimique agricole, Agricultural chemical, Travaux agricoles, Agriculture operation, Pesticide

Numéro de projet IRSST

2015-0013

Citation recommandée

Khemiri, R., Côté, J., Fetoui, H. et Bouchard, M. (2018). Kinetic time courses of lambda-cyhalothrin metabolites after dermal application of Matador EC 120 in volunteers. Toxicology Letters, 296, 132-138. https://doi.org/10.1016/j.toxlet.2018.08.008