Biological activities of interleukin (IL)-21 in human monocytes and macrophages

Auteurs

Francis Vallières, Laboratoire de recherche en inflammation et physiologie des granulocytes, Université du Québec, INRS-Institut Armand-Frappier, Laval, Québec, Canada
Isabelle Durocher, Laboratoire de recherche en inflammation et physiologie des granulocytes, Université du Québec, INRS-Institut Armand-Frappier, Laval, Québec, Canada
Denis Girard, Laboratoire de recherche en inflammation et physiologie des granulocytes, Université du Québec, INRS-Institut Armand-Frappier, Laval, Québec, Canada

Type de document

Études primaires

Année de publication

2019

Langue

Anglais

Titre de la revue

Cellular Immunology

Première page

62

Dernière page

70

Résumé

The biological roles of interleukin (IL)-21 in human monocytes and macrophages have been neglected. We previously demonstrated that IL-21 induce phagocytosis and established that Syk is a new molecular target of IL-21. Herein, we found that IL-21 is not chemoattractant for immature THP-1 and primary monocytes but can increase the capacity of THP-1 cells (not primary monocytes) to adhere onto a cell substratum by a Syk-dependent mechanism without altering the expression of a panel of cell surface molecules. Unlike THP- 1 and monocytes, IL-21 can increase metalloproteinase (MMP)-9 secretion and activity in monocyte-derived macrophages (HMDM), as assessed by western blot and zymography experiments, respectively. We reported that IL-21 did not increase the production of IL-6 and the chemokines MIP-1α and GRO-α in HMDM. Therefore, IL-21 can increase functions other that phagocytosis, but this cytokine does not have a large spectrum of biological activities in monocytes and macrophages. © 2019 Elsevier Inc.

Mots-clés

Macrophage, Biologie, Biology, Cancer

Numéro de projet IRSST

2012-0053

Citation recommandée

Vallières, F., Durocher, I. et Girard, D. (2019). Biological activities of interleukin (IL)-21 in human monocytes and macrophages. Cellular Immunology, 337, 62-70. https://doi.org/10.1016/j.cellimm.2019.02.002