Metabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances

Type de document

Revues de littérature, synthèses de connaissances

Année de publication

2020

Langue

Anglais

Titre de la revue

European Journal of Neuroscience

Première page

396

Dernière page

412

Résumé

Shift work, defined as work occurring outside typical daytime working hours, is associated with an increased risk of various non-communicable diseases, including diabetes and cardiovascular disease. Disruption of the internal circadian timing system and concomitant sleep disturbances is thought to play a critical role in the development of these health problems. Indeed, controlled laboratory studies have shown that short-term circadian misalignment and sleep restriction independently impair physiological processes, including insulin sensitivity, energy expenditure, immune function, blood pressure and cardiac modulation by the autonomous nervous system. If allowed to persist, these acute effects may lead to the development of cardiometabolic diseases in the long term. Here, we discuss the evidence for the contributions of circadian disruption and associated sleep disturbances to the risk of metabolic and cardiovascular health problems in shift workers. Improving the understanding of the physiological mechanisms affected by circadian misalignment and sleep disturbance will contribute to the development and implementation of strategies that prevent or mitigate the cardiometabolic impact of shift work. © 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd

Mots-clés

Travail par postes, Shift work, Perturbation métabolique, Metabolic disturbance, Trouble cardiovasculaire, Cardiovascular disorder, Rythme circadien, Circadian rhythm, Perturbation du sommeil, Sleep disturbance

Numéro de projet IRSST

2013-0046

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