Use of the novel derivatizing agent 1,8-diaminonapthalene with the CIP10 sampler to measure 4,4'-methylene diphenyl diisocyanate atmospheres

Auteurs

Silvia Puscasu, IRSSTFollow
Simon Aubin, IRSSTFollow
Philippe Sarazin, IRSSTFollow
Lucile Richard, IRSSTFollow
Mark Spence
Sébastien Gagné, IRSSTFollow

Type de document

Études primaires

Année de publication

2017

Langue

Anglais

Titre de la revue

Annals of Work Exposures and Health

Première page

566

Dernière page

574

Résumé

DAN is a novel derivatizing agent for isocyanate sampling which targets total reactive isocyanate group (TRIG). Field evaluations have been conducted for 4,4’-Methylene diphenyl diisocyanate (MDI) sampling using DAN as the derivatizing agent in a CIP10. The perimidone formed, selective of TRIG, was analyzed in laboratory by liquid chromatography coupled to tandem mass spectrometry. Workplaces using MDI-based polyurethane spray foam and MDI wood product binder were studied. Each study compared the data obtained between the CIP10/DAN, the CIP10/MP, and a reference method. As a first evaluation, the CIP10/DAN sampled simulated MDI spray foam atmosphere in parallel with impingers (reference method) and CIP10/MP. The mean of the TRIG concentration values measured was 16% (95% confidence interval [CI], [1, 31]) higher for the CIP10/MP samples as compared to the impinger samples, while the mean TRIG concentrations found were 98% (95% CI [63, 133]) higher for the CIP10/DAN samples as compared to the impinger samples. For sampling done in a real workplace using MDI-based spray foam, the CIP10/DAN method showed lower results than the CIP10/MP method. The presence of hygroscopic DMSO used in the DAN approach is a limitation and may prevent obtaining accurate results in the spray foam atmosphere. CIP10/DAN was also studied in MDI wood product binder atmosphere. Mean TRIG concentrations found were 80% (95% CI [51, 110]) and 79% (95% CI [50, 108]) lower for the CIP10/MP and CIP10/DAN method, respectively, as compared to the reference method (a 13-mm filter coated with MP). In this case, the CIP10 may have reached its limit in this last evaluation where vapors and particles below 1 µm were not collected as efficiently as they were with the reference method.

Mots-clés

Diisocyanate de diphénylméthane, Diphenylmethane diisocyanate, CAS 101688, Échantillonnage et analyse, Sampling and analysis, Isocyanates, Aérosol, Aerosol, Analyse par comparaison, Comparative analysis, Isolant thermique, Thermal insulating material, Essai du matériel, Equipment testing, Québec

Numéro de projet IRSST

n/a

Citation recommandée

Puscasu, S., Aubin, S., Sarazin, P., Richard, L., Spence, M. et Gagné, S. (2017). Use of the novel derivatizing agent 1,8-Diaminonapthalene with the CIP10 sampler to measure 4,4’-Methylene Diphenyl Diisocyanate atmospheres. Annals of Work Exposures and Health, 61(5), 566-574. https://doi.org/10.1093/annweh/wxx023