Impact of palladium nanoparticles (Pd-NPs) on the biology of neutrophils in vitro and on leukocyte attraction in vivo
Type de document
Études primaires
Année de publication
2021
Langue
Anglais
Titre de la revue
Journal of Nanoparticle Research
Résumé
Recently, palladium nanoparticles (Pd-NPs) have been shown to possess pro-inflammatory activities. Herein, we investigated potential in vitro effects of Pd-NPs (primary size of 1–10 nm) on the biology of neutrophils, key player cells in inflammation. Also, the aim of this study was to evaluate the pro-inflammatory activity of Pd-NPs using the murine air pouch model, a model previously proposed to be used as a standard assay for testing in vivo pro-inflammatory effects of NPs. Although the positive controls used in vitro give the expected results in all biological functions tested, Pd-NPs do not affect the production of reactive oxygen species and that of interleukin-1β (IL-1β), IL-6, and IL-8. Pd-NPs moderately increase cellular adhesion of neutrophils onto human endothelial cells and significantly increase the capacity of neutrophils to migrate and to delay apoptosis. We conclude that Pd-NPs possess some pro-inflammatory activity in vitro but do not attract leukocytes in vivo regardless of sex.
Mots-clés
Nanoparticule, Nanoparticle, Palladium, CAS 7440053, Recherche in vitro, In vitro experiment, Recherche sur l'animal, Animal experiment, Toxicocinétique, Toxicokinetics, Leucocyte, Leukocyte, Altération des neutrophiles Neutrophil change
Numéro de projet IRSST
n/a
Citation recommandée
Kwemo, P., Saafane, A., Vanharen, M., Durocher, I. et Girard, D. (2020). Impact of palladium nanoparticles (Pd-NPs) on the biology of neutrophils in vitro and on leukocyte attraction in vivo. Journal of Nanoparticle Research, 22(11), article 350. https://doi.org/10.1007/s11051-020-05079-z