Inter-rater reliability of occupational exposure assessment in a case-control study of female breast cancer

Type de document

Études primaires

Année de publication

2021

Langue

Anglais

Titre de la revue

Journal of Occupational and Environmental Hygiene

Première page

522

Dernière page

531

Résumé

The objective of this paper was to estimate the inter-rater reliability of expert assessments of occupational exposures. An inter-rater reliability sub-study was conducted within a population-based case-control study of postmenopausal breast cancer. Detailed information on lifetime occupational histories was obtained from participants and two industrial hygienists assigned exposures to 185 jobs using a checklist of 293 agents. Experts rated exposure for each job–agent combination according to exposure status (unexposed/exposed), confidence that the exposure occurred (possible/probable/definite), intensity (low/medium/high), and frequency (% time per week). The statistical unit of observation was each job–agent assessment (185 jobs × 293 agents = 54,205 assessments per expert). Crude agreement, Gwet AC1/2 statistics, and Cohen’s Kappa were used to estimate inter-rater agreement for confidence and intensity; for frequency, the intra-class correlation coefficient (ICC) was used. The majority of job–agent combinations were evaluated by the two experts to be not exposed (crude agreement >98% of decisions). The degree of agreement between the experts for the confidence of exposure status was Gwet AC1/2 = 0.99 (95% CI: 0.99–0.99), and for intensity, a Gwet AC2 = 0.99 (95% CI: 0.99–0.99). For frequency, an ICC of 0.31 (95% CI: 0.26–0.35) was found. A sub-analysis restricted to job–agent combinations for which the two experts agreed on exposure status revealed a moderate agreement for confidence of exposure (Gwet AC2 = 0.66) and high agreement for intensity (Gwet AC2 = 0.96). For frequency, the ICC was 0.52 (95% CI: 0.47–0.57). A high level of inter-rater agreement was found for identifying exposures and for coding intensity, but agreement was lower for the coding of frequency of exposure.

Mots-clés

Évaluation de l'exposition, Exposure evaluation, Cancer du sein, Breast cancer, Femme, Woman, Produit chimique, Chemical product, Évaluation du risque, Hazard evaluation, Matrice emploi exposition, Employment exposure matrix, CANJEM, JEM

Numéro de projet IRSST

2017-0038

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