Type de document
Études primaires
Année de publication
2016
Langue
Anglais
Titre de la revue
Journal of Occupational and Environmental Hygiene
Première page
598
Dernière page
603
Résumé
Accurate measurement of 4,4'-methylene diphenyl diisocyanate (MDI) atmospheres is a challenge since the molecule is both chemically reactive and likely to be present in aerosol form when heated and sprayed because of its low vapor pressure. Meeting this challenge requires optimizing both the sampling device used and the derivatization agent employed to stabilize the isocyanate functional group. This study describes the use of a novel derivatization reagent for isocyanate sampling to address the challenge of MDI aerosol exposure sampling. Like most conventional derivatizing agents for isocyanates, 1,8-diaminonapthalene (DAN) reacts with isocyanate functional groups to form a urea. However, unlike other isocyanate derivatizing agents, the sample workup procedure with DAN includes a second step which yields a single analyte molecule, perimidone, for each isocyanate group. This feature gives DAN the unique ability to assess exposure to “total reactive isocyanate group” (TRIG). The analytical method implemented to quantitate the perimidone uses liquid chromatography coupled with tandem mass spectrometry. Positive mode ionization led to LOD and LOQ of 10 ng/mL and 34 ng/mL, respectively. The dynamic range was from 50–2000 ng/mL (with R2 ≥ 0.990), which corresponds to TRIG concentrations in air from 0.07–3.04 µg/m3, assuming 60 min of sampling at 10 L/min (based on use of the CIP-10M sampler). The intra-day and inter-day analytical precisions were <4% for all of the concentration levels tested, and the accuracy was within an appropriate range of 98 ± 2%. Minimal matrix effect was observed, and a total recovery of 109% was obtained. The approach seems to be promising for TRIG measurements and further work is planned to establish DAN method behavior in samplers used for workplace monitoring.
Mots-clés
Diisocyanate de méthylène, Methylene diisocyanate, CAS 4747904, Aérosol, Aerosol, Échantillonnage dans l'air, Air sampling, Isocyanates, Ionisation, Chromatographie en phase liquide, Liquid phase chromatography
Numéro de projet IRSST
n/a
Citation recommandée
Puscasu, S., Aubin, S., Spence, M. et Gagné, S. (2016). Implementation and evaluation of an analytical method for a novel derivatizing agent to measure 4,4'-methylene diphenyl diisocyanate atmospheres. Journal of Occupational and Environmental Hygiene, 13(8), 598-603. https://doi.org/10.1080/15459624.2016.1159691
Included in
Analytical Chemistry Commons, Occupational Health and Industrial Hygiene Commons, Toxicology Commons